Association of body fat distribution with depression and social anxiety in children and adolescents: A cross-sectional study based on dual-energy X-ray detection / 北京大学学报(医学版)

OBJECTIVE@#To investigate the status of depression and social anxiety in children and adolescents, and to analyze the association between body fat distribution and depression, social anxiety in children and adolescents.@*METHODS@#A total of 1 412 children aged 7 to 18 years in Beijing were included by stratified cluster random sampling method. Body fat distribution, including total body fat percentage (total BF%), Android BF%, Gynoid BF% and Android-to-Gynoid fat ratio (AOI), were obtained by dual-energy X-ray absorption method. Depression and social anxiety were evaluated by Children Depression Inventory and Social Anxiety Scale for Children. Multivariate linear regression and restricted cubic spline analysis were used to estimate the linear and non-linear correlation between body fat distribution and depression and social anxiety.@*RESULTS@#13.1% and 31.1% of the children and adolescents had depressive symptoms and social anxiety symptoms respectively, and the detection rate of depression and social anxiety in the boys and young groups was significantly lower than those in the girls and old groups. There was no significant linear correlation between total BF%, Android BF%, Gynoid BF%, AOI and depression and social anxiety in the children and adolescents. However, total BF% and Gynoid BF% had significant nonlinear correlation with depression, showing an inverted U-shaped curve relationship with the tangent points of 26.8% and 30.9%, respectively. In terms of the nonlinear association of total BF%, Android BF%, Gynoid BF% and AOI with depression and social anxiety, the change trends of the boys and girls, low age group and high age group were consistent. The overall anxiety risk HR of body fat distribution in the boys was significantly higher than that in the girls, and the risk HR of depression and social anxiety were significantly higher in the high age group than those in the low age group.@*CONCLUSION@#There was no significant linear correlation between body fat distribution and depression and social anxiety in children and adolescents. Total BF% and depression showed an inverted U-shaped curve, mainly manifested in Gynoid BF%, and this trend was consistent in different genders and different age groups. Maintaining children and adolescents' body fat distribution at an appropriate level is the future direction of the prevention and control of depression and social anxiety in children and adolescents.

Modelo preclínico de obesidad basado en alimentos altamente procesados y de alta palatabilidad / Preclinical model of obesity based on ultra-processed and highly palatable foods

Resumen Introducción: el alarmante incremento de la obesidad en todo el mundo y en Costa Rica responde principalmente a modificaciones en la composición de la dieta habitual de las personas. La presente investigación tuvo como objetivo implementar un protocolo de alimentación formulado a partir de alimentos altamente procesados y de alta palatabilidad (APAP) consumidos por la población costarricense para, luego, evaluar sus efectos en la conducta alimentaria y en parámetros biométricos y bioquímicos. Metodología: ratas adultas macho Wistar se asignaron a dos grupos. Al primero se le administró alimento estándar para roedores (grupo DC) y al segundo, alimentos APAP (grupo APAP), durante ocho semanas. Resultados: a lo largo de ese periodo, los animales expuestos a los APAP exhibieron mayor ingesta y energía, caracterizadas por un alto consumo de grasas y uno menor de proteínas y fibra; además, mostraron un incremento significativo en los diversos parámetros de obesidad (e. g., peso corporal y ganancia de peso, índice de Lee y adiposidad central) y niveles descriptivamente superiores de glucosa y triglicéridos en sangre, pero notablemente menores de colesterol total. Conclusiones: los resultados indican que una dieta basada en los alimentos APAP más frecuentes en la población costarricense es capaz de inducir hiperfagia y obesidad. Así, este modelo constituye una herramienta prometedora para ahondar en el estudio de las factores neurobiológicos y metabólicos relacionados con la obesidad por el sobreconsumo de alimentos APAP.

Abstract Introduction. The alarming increase in obesity both worldwide and in Costa Rica is mainly due to changes in the composition of the usual diet of the population. The goal of our research was to implement a feeding protocol formulated from ultra-processed and highly palatable foods (UPHP) consumed by the Costa Rican population and to evaluate the effects of the UPHP diet on eating behavior and biometric and biochemical parameters. Methods: Adult male Wistar rats were assigned to two groups. One group was given standard rodent chow (DC group) while the other group received UPHP foods (UPHP group) for eight weeks. Results: Throughout this period, animals exposed to the UPHP diet exhibited higher food and energy intake characterized by high consumption of fat and lower consumption of protein and fiber. Animals in the UPHP group also showed a significant increase in obesity parameters (e.g., body weight and bodyweight gain, Lees index, and central adiposity). Furthermore, the UPHP group had descriptively higher levels of blood glucose and triglycerides and significantly lower levels of total cholesterol. Conclusions: Our results indicate that a feeding protocol based on the most frequent food choices of the Costa Rican population is capable of inducing hyperphagia and obesity. This model constitutes a promising tool to delve into the study of the neurobiological and metabolic factors related to obesity induced by overconsumption of UPHP foods.

Índice de masa corporal, peso ideal y porcentaje de grasacorporal en personas de diferentes grupos etarios / Body mass index, ideal weight and percentage of body fat inpeople of different age groups

El objetivo es comparar el IMC con el porcentaje de grasa corporal y el peso ideal, para complementar el IMC en el diagnóstico de obesidad, de un grupo de adultos. Métodos: estudio descriptivo, transversal, prospectivo y correlacional, en una muestra de 797 adultos con edad entre 17 y 96 años, atendidos en diferentes centros clínicos de Caracas, entre 2015 y 2018. Las variables son: edad, peso, talla y se calcularon el IMC, porcentaje de grasa corporal (PGC) y peso ideal (PI). Se clasificaron por sexo, grupo etáreo y según el IMC en normalidad y obesidad. Se utilizaron dos fórmulas para el PGC: Deurenberg y Regresión; y tres fórmulas para PI: Lorenz, Ramírez et al y Broca. Se obtuvieron medidas descriptivas, asociación, correlación, comparación de promedios y prueba de normalidad, mediante el soware Excel, Epidat.2. Resultados: Promedios de IMC y PGC aumentan hasta los 40 años y disminuye hasta los 79 años, las variables Talla ­ PI Broca, e IMC- PGCR correlacionan bien (r>0,75). Los promedios del IMC, PGCD, PGCR, PI Broca y PI Lorenz, según sexo, son significativos (p<0,000); para el IMC, en Normalidad y Obesidad, los promedios de peso, IMC, PGCD y PGCR son mayores en grupo de Obesidad, y significativos (p<0,000). La prueba de normalidad Shapiro-Francia comprobó que la distribución del IMC, PGCD, PGCR y PI Lorenz, provienen de una población distribuida normalmente (p< 0,000). Conclusiones: el IMC aun cuando es utilizado más frecuentemente para diagnosticar obesidad, clasifica con normalidad, a quienes tienen un alto porcentaje de grasa corporal(AU)

The objective is to compare BMI with the percentage of body fat and ideal weight, to supplement BMI in the diagnosis of obesity, from a group of adults. METHODS: descriptive, cross-cutting, prospective and correlational study, in a sample of 797 adults between 17 and 96 years old, attended in different clinical centers of Caracas, between 2015 and 2018. the variables are: age, weight, size and BMI was calculated, percentage of body fat (BFP) and ideal weight (IW). they were classified by sex, age group and BMI in normality and obesity. Two formulas were used for BFP: Deurenberg and Regression; and three formulas for IW: Lorenz, Ramirez-Lopez et al and Broca. Descriptive measures, association, correlation, average comparison and normality test were obtained, using Excel software, Epidat.2. RESULT: BMI and BFP averages increase to 40 years and decrease to age 79, the variables Size ­ IW Broca, and BMI- BFPR correlate well (r>0.75). e average BMI, BFPD, BFPR, IW Broca and IW Lorenz, depending on gender, are significant (p<0.000); for BMI, in Normality and Obesity, the weight averages, BMI, BFPD and BFPR are higher in the Obesity group, and significant (p<0,000). the Shapiro-France normality test found that the distribution of BMI, BFPD, BFPR and IW Lorenz, comes from a normally distributed population (p< 0.000). CONCLUSIONS: BMI even though it is most commonly used to diagnose obesity, it classifies normally, those with a high percentage of body fat(AU)

Tiempo dedicado a actividades físicas de diferente intensidad y su relacion con variables antropométricas y grasa corporal en escolares costarricenses / Time dedicated to physical activities of different intensity and its relationship with anthropometic variables and body fat in Costa Rican schoolchildren

Introducción: La realización de actividad física es de relevancia en la prevención del sobrepeso y la obesidad infantil. Objetivo: Determinar la asociación entre el tiempo que dedican escolares costarricenses a actividades físicas de diferentes intensidades con variables antropométricas y con el porcentaje de grasa corporal. Materiales y métodos: Participaron 21 niños y 11 niñas con edades entre los 6 a 9 años. Las mediciones antropométricas fueron: peso, talla, circunferencia de brazo, circunferencia de cintura, pliegue subescapular, pliegue tricipital. Se calculó el IMC, circunferencia muscular del brazo, área del brazo, área muscular del brazo, área grasa del brazo e índice cintura/talla. El análisis del porcentaje de grasa corporalse realizó por el método del deuterio. El tiempo dedicado a la actividad física a diferente intensidad se registró por medio del acelerómetro Actiheart y las variables registradas fueron en condición sedentaria, ligera, moderada, vigorosa y moderada + vigorosa. Resultados: Los niños presentaron valores significativamente mayores (p < 0.05) en la condición moderada, vigorosa y moderada + vigorosa que las niñas. El análisis de correlación de Pearson determinó una asociación negativa entre el tiempo de actividad física moderado y moderado + vigorosa intensidad con el peso, IMC, circunferencia de cintura, pliegue cutáneo tricipital y porcentaje grasa corporal. Conclusiones: Los escolares entre 6 a 9 años que dedican más tiempo a las actividades de moderada intensidad y a las de moderada + vigorosa intensidad disminuyen factores de riesgo relacionados con el desarrollo de enfermedades no transmisibles

Introduction: Physical activity is important in the prevention of childhood overweight and obesity. Objective: To determine the association between the time that Costa Rican schoolchildren dedicate to physical activities of different intensities with anthropometric variables and with the percentage of body fat. Materials and methods: Participants were 21 boys and 11 girls with ages between 6 and 9 years old. Anthropometric measurements were weight, size, arm circumference, waist circumference, sub scapular fold, tricipital fold. BMI, arm muscle circumference, arm area, arm muscle area, fat arm area, and waist/height ratio were calculated. Analysis of the percentage of body fat was carried out by the deuterium method. The time devoted to physical activity at different intensity was recorded using the Actiheart accelerometer and the variables recorded were sedentary, light, moderate, vigorous and moderate + vigorous condition. Results: Boys presented significantly higher values (p <0.05) in the moderate, vigorous and moderate + vigorous condition than girls. Pearson's correlation analysis determined a negative association between moderate physical activity time and moderate + vigorous intensity with weight, BMI, waist circumference, triceps skinfold, and body fat percentage. Conclusions: Schoolchildren between 6 and 9 years of age who dedicate more time to activities of moderate intensity and moderate + vigorous intensity reduce risk factors related to the development of non-communicable diseases

Valor diagnóstico de indicadores antropométricos para sobrepeso y obesidad / Diagnostic value of anthropometric indicators for overweight and obesity

La obesidad se define por un exceso de masa grasa, sin embargo, hay otros indicadores antropométricos que pueden ser útiles para el diagnóstico de sobrepeso u obesidad; Objetivo. Determinar la exactitud diagnóstica del índice de masa corporal (IMC), circunferencia de la cintura (CC) e índice de forma corporal (ABSI) para el diagnóstico de sobrepeso u obesidad en una población adulta del Ecuador. Materiales y métodos. Se desarrolló un estudio observacional de corte transversal en el que participaron 253 sujetos con edades entre 20 y 60 años. Se midió peso, estatura, circunferencia de la cintura y porcentaje de grasa corporal (PGC). Se correlacionó el PGC con IMC, CC y ABSI y se estableció la sensibilidad y especificidad de estos indicadores para el diagnóstico de sobrepeso u obesidad con curvas ROC. Resultados. El PGC fue menor en hombres que en mujeres (30,9 vs 41,87), ABSI y CC fue mayor en hombres que en mujeres (0,079 vs 0,075) y (99,76 vs 91,25) respectivamente. Se encontró una correlación positiva fuerte (≥0,75) entre el PGC e IMC y CC. En la curva ROC, el área bajo la curva más alta se observa para el IMC (0,949), mientras que el área más baja se observa para ABSI (0,395). Conclusión. El IMC es el indicador con mayor precisión diagnóstica de sobrepeso u obesidad. ABSI no sería un indicador útil en el diagnóstico de sobrepeso u obesidad(AU)

Obesity is defined by an excess of fat mass, however, there are other anthropometric indicators that can be useful for the diagnosis of overweight or obesity; Objetive. To determine the diagnostic accuracy of the body mass index (BMI), waist circumference (WC) and body shape index (ABSI) for the diagnosis of overweight or obesity in an adult population of Ecuador. Materials and methods. An observational cross-sectional study was carried out in which 253 subjects aged between 20 and 60 years participated. Weight, height, waist circumference and percentage body fat (PBF) were measured. The PBF was correlated with BMI, WC and ABSI and the sensitivity and specificity of these indicators were established for the diagnosis of overweight or obesity with ROC curves. Results. The PBF was lower in men than in women (30.09 vs 41.87), ABSI and CC were higher in men than in women (0.079 vs 0.075) and (99.76 vs 91.25) respectively. A strong positive correlation (≥0.75) was found between % body fat and BMI and WC. On the ROC curve, the area under the highest curve is observed for BMI (0.949), while the lowest area is observed for ABSI (0.395). Conclusion. The BMI is the indicator with the highest diagnostic precision of overweight or obesity. ABSI would not be a useful indicator in the diagnosis of overweight or obesity(AU)

Referencias de índice de masa corporal. Precisión diagnóstica con área grasa braquial en escolares argentinos / Body mass index references. Diagnostic accuracy with the upper-arm fat area in Argentine schoolchildren

El índice de masa corporal (IMC) es una eficaz herramienta para detectar la sobrecarga ponderal en niños y adolescentes, asociado a la adiposidad corporal. Objetivo. Analizar la concordancia, sensibilidad y especificidad de tres referencias internacionales de IMC/edad (OMS, IOTF y CDC) para diagnosticar el exceso ponderal y conocer su precisión diagnóstica para identificar el exceso de adiposidad con relación al área grasa braquial (AGB) en población infanto juvenil de Argentina. Materiales y métodos. Se realizó un estudio multicéntrico, descriptivo-comparativo y transversal entre 2003 y 2008, en 22.658 niños y adolescentes argentinos de 4 a 13 años de edad. A partir del peso, talla, circunferencia del brazo y pliegue tricipital, se calcularon IMC y AGB. Se analizó la concordancia, sensibilidad y especificidad de referencias de IMC/edad (OMS, CDC, IOTF) y la precisión diagnóstica (curvas ROC) para identificar exceso de adiposidad, a partir del AGB, así como el punto de corte óptimo (PCO). Resultados. Las tres referencias tuvieron buena concordancia. La mayor sensibilidad correspondió a OMS y la mayor especificidad a IOTF. El área bajo la curva (ABC) fue mayor en Z-IMC/IOTF en varones y en Z-IMC/OMS en mujeres. Los PCO mostraron discrepancias, siendo mayores con OMS. Conclusión. Las tres referencias muestran similar precisión diagnóstica para detectar alta reserva calórica, con puntos de corte óptimo para las puntuaciones Z-IMC menores a 2 Z scores. Esto resulta relevante para la identificación de exceso de adiposidad en poblaciones, en relación con la implementación de políticas públicas de prevención de enfermedades crónicas no transmisibles(AU)

The body mass index (BMI) is an effective tool to detect weight overload in children and adolescents, associated with body adiposity. Objective. To analyze the concordance, sensitivity and specificity of three international BMI/age references (WHO, IOTF and CDC) to diagnose excess weight and to know their diagnostic accuracy to identify excess adiposity in relation to the brachial fat area (BFA) in Argentine child-youth population. Materials and methods. A multicenter, descriptive- comparative and cross-sectional study was carried out between 2003 and 2008 in 22.658 Argentine children and adolescents between aged 4 to 13 years. From the weight, height, arm circumference and tricipital fold, BMI and BFA were calculated. The concordance, sensitivity, and specificity of BMI / age references (WHO, IOTF, CDC,) were analyzed and the diagnostic precision (ROC curves) to identify excess adiposity, from the BFA, as well as the optimal cut-off point (OCP). Results. The three references had good agreement, the highest sensitivity corresponded to WHO and the highest specificity to IOTF. The area under the curve (AUC) was greater in Z-BMI/IOTF in men and in Z-BMI/WHO in women. The OCPs showed discrepancies, being higher with WHO. Conclusion. The three references show similar diagnostic accuracy to detect high caloric reserve, but with cut-off points for Z-BMI scores less than 2 Z scores. This is relevant for the identification of excess adiposity in populations in relation to the implementation of public policies for the prevention of chronic non-communicable diseases(AU)

Association of cigarette and water-pipe smoking with increased visceral adiposity, glycemic intolerance and hematological derangement in Iraqi healthy smokers

Abstract The present study aims to investigate the impacts of cigarette smoking (CS) and water-pipe smoking (WPS) on the visceral adiposity index (VAI), hematological characteristics, and glycemic tolerance in Iraqi healthy smokers. A total of 528 healthy males from different locations of Baghdad city were allocated to three groups; nonsmokers (176), cigarette smokers (178), and WP smokers (174). Baseline characteristics, anthropometric and hematological markers and were reported. Glycemic control was evaluated using the glucose tolerance test. The evidence of elevated VAI, disrupted hematological markers, and impaired glucose tolerance was significantly (P<0.001) different compared with non-smokers and related to the duration of smoking. The impacts of WPS seem to be significantly greater than CS in certain parameters (hemoglobin, hematocrit, methemoglobin, and 2-hour glucose tolerance values). In conclusion, CS and WPS negatively impacted body fat distribution, glucose tolerance, and hematological markers. There is a positive association between the rate of smoking and obesity, glycemic intolerance in both groups

Body fat distribution and its risk for cardiovascular events in 10 years: Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) / A distribuição de gordura corporal está relacionada ao risco de eventos cardiovasculares em 10 anos: Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil) / La distribución de la grasa corporal está relacionada con el riesgo de eventos cardiovasculares en 10 años: Estudio Longitudinal de Salud en Adultos (ELSA-Brasil)

Body fat distribution seems to have different effects in cardiovascular diseases (CVD). We aimed to estimate the associations between lower limbs and trunk fat ratio and the 10-year CVD risk, and isolated risk factors in men and women. A total of 10,917 participants from ELSA-Brasil were eligible for this cross-sectional study. Associations between lower limb/trunk fat ratio with the percentage of 10-year CVD risk - according to the Framingham Risk Score - and its risk factors (systolic blood pressure, total cholesterol and HDL-cholesterol, diabetes, and use of antihypertensive medication) were performed using generalized linear models, linear and logistic regressions. All analyses were stratified by gender and adjustments were made by age, self-reported skin color, educational attainment, alcohol consumption, leisure physical activity, hypolipidemic drug use and, for women, menopausal status. In this study, 55.91% were women, with a mean age of 52.68 (SD = 6.57) years. A higher lower limb/trunk fat ratio was related to lower 10-year CVD risk, as well as a reduction in systolic blood pressure, total cholesterol, and antihypertensive drug use, also an increasing HDL-cholesterol in both genders, but this relationship was stronger in women. Besides, a protective relationship to diabetes was observed in women. Higher fat accumulation in the lower body, when compared to the trunk, seems to have a lower risk of CVD and associated risk factors - even in the presence of fat in the abdominal region - with women presenting lower risks than men.

A distribuição de gordura no corpo parece ter efeitos diferentes nas doenças cardiovasculares (DCV). Objetivou-se estimar as associações da razão de gordura entre membros inferiores e tronco com o risco de DCV em 10 anos e os fatores de risco independentes em homens e mulheres. Um total de 10.917 participantes do ELSA-Brasil eram elegíveis para este estudo transversal. As associações da razão de gordura entre os membros inferiores e tronco com o percentual de risco de DCV em 10 anos, de acordo com a Escala de Risco de Framingham, e os respectivos fatores de risco (pressão arterial sistólica, colesterol total e HDL colesterol, diabetes e uso de medicação anti-hipertensiva), foram avaliados com modelos lineares generalizados, lineares e de regressão logística. Todas as análises foram estratificadas por sexo, e os ajustes foram feitos por idade, raça/cor, escolaridade, consumo de álcool, atividade física, uso de medicação hipolipemiante e, para as mulheres, estado de menopausa. Na amostra do estudo atual, 55,91% eram mulheres, com média de idade de 52,68 anos (DP = 6,57). A maior diferença entre a gordura dos membros inferiores e tronco foi associada com menor risco de DCV em 10 anos e com redução na pressão arterial sistólica, colesterol total e uso de medicação anti-hipertensiva, assim como um aumento no HDL colesterol em ambos os sexos (mas essa correlação foi mais forte em mulheres). Além disso, foi observada uma relação protetora contra diabetes, apenas em mulheres. O acúmulo maior de gordura nos membros inferiores, comparado com o tronco, parece estar associado a um risco menor de DCV e aos fatores de risco, mesmo na presença de gordura na região abdominal, e esse efeito é mais forte nas mulheres que nos homens.

Las distribuciones de grasa corporal parecen tener diferentes efectos en las enfermedades cardiovasculares (ECV). Nuestro objetivo fue estimar las asociaciones entre extremidades inferiores/ratio de grasa troncal y el riesgo de ECV a los 10 años, y sus factores de riesgo aislados, en hombres y mujeres. Un total de 10.917 participantes de ELSA-Brasil fueron elegibles para este estudio transversal. Las asociaciones de la ratio de grasa entre la parte inferior del cuerpo y el tronco, con el porcentaje de riesgo de ECV a los 10 años, según la Escala de Riesgo de Framingham, y sus factores de riesgo (presión sanguínea sistólica, colesterol total y colesterol HDL, diabetes, y uso de medicación antihipertensiva), se realizaron usando modelos lineales generalizados, regresiones lineales y logísticas. Todos los análisis fueron estratificados por sexo y los ajustes se hicieron por edad, raza/color de piel autoinformado, nivel educativo, consumo de alcohol, actividad física durante el ocio, uso de medicamentos hipolipemiantes y, para mujeres, estatus menopáusico. En este estudio, un 55,91% fueron mujeres, con una media de edad de 52,68 (SD = 6,57) años. Una ratio de masa adiposa más alta entre las extremidades inferiores/tronco estuvo asociada a un riesgo menor de ECV en 10 años, también una reducción en la presión sistólica sanguínea, colesterol total, y el consumo de medicamentos antihipertensivos, también en un incremento del colesterol HDL en ambos sexos, pero esta relación fue más fuerte en mujeres. Asimismo, una relación protectora frente a la diabetes se observó solo en mujeres. Una acumulación más alta de grasa en las extremidades inferiores, comparada con la del tronco, parece tener un riego más bajo de ECV y sus factores de riesgo, incluso con la presencia de grasa en la región abdominal, además este efecto es más fuerte en mujeres comparadas con los hombres.

Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein

Abstract We investigated whether coconut milk protein (CMP) contributes to the beneficial effects of coconut milk consumption on cardiovascular health markers previously found in middle-aged rats. CMP was isolated and precipitated from dried fresh coconut milk, then gavaged (1 g/kg) to middle-aged male rats for six weeks; control rats received distilled water. Compared to controls, CMP caused decreased body fat and lipid accumulation in liver cells and the platelet count. CMP did not affect basal blood pressure or heart rate in anesthetized rats. Vascular responsiveness to phenylephrine, DL-propargylglycine (PAG), acetylcholine or sodium nitroprusside was unaffected, but vasorelaxation to glyceryl trinitrate (GTN) increased. Effects of ODQ on vasorelaxation to GTN were similar in both groups. Expression of blood vessel eNOS, CSE and sGC was normal. The cyclic guanosine monophosphate (cGMP) level of CMP-treated rats was normal but addition of GTN increased cGMP and NO concentration more in CMP-treated rats than in controls, an effect unaltered by addition of diadzin. Taken together, CMP appears partially responsible for the improvement in cardiovascular health markers caused by coconut milk in middle-aged male rats

Association of aerobic fitness and body composition in people with down syndrome / Associação de aptidão aeróbia e composição corporal em pessoas com síndrome de down

ABSTRACT People with Down Syndrome (DS) present metabolic differences when compared to the general population, which ends up at a higher prevalence of overweight and lower rates of aerobic fitness. The aim of this study was analysing the association of aerobic fitness and body composition in individuals with DS. Thirty individuals with DS from the city of Londrina / Brazil with a mean age of 18.00±3.66 years were evaluated. The variables body mass index, body fat, and aerobic fitness (VO²peak) were investigated. Men were taller than women, presented a higher percentage of lean body mass and higher VO²peak, while women showed higher means for android, gynoid and total fat. Aerobic fitness was positively associated with bone mineral density and inversely associated with nutritional status, lean body mass and body fat.

RESUMO Pessoas com Síndrome de Down (SD) apresentam diferenças metabólicas quando comparadas à população em geral, o que resulta em maior prevalência de sobrepeso e menores índices de aptidão aeróbia. O objetivo deste estudo foi analisar a associação da aptidão aeróbia com a composição corporal em indivíduos com SD. Foram avaliados 30 indivíduos com SD da cidade de Londrina / Brasil com média de idade 18,00±3,66 anos. Foram investigadas as variáveis índice de massa corporal, gordura corporal, e aptidão aeróbia (VO²pico). Os homens foram mais altos que as mulheres, apresentaram maior percentual de massa magra e maior VO²pico, enquanto as mulheres apresentaram maiores médias para gordura andróide, ginóide e total. A aptidão aeróbia associou-se inversamente ao índice de massa corporal, massa magra e gordura corporal.

Profile for body fat percentage of Serbian working population, aged from 18 to 65, measured by multichannel bioimpedance method / Perfil del porcentaje de grasa corporal de la población activa serbia, de 18 a 65 años, medido por el método de bioimpedancia multicanal

SUMMARY: Obesity prevalence and trends of PBF related to age were defined on a sample of 8100 people among whom, 4955 were male (Age = 31.2 ± 10 yr) and 3145 were female (Age = 32.1 ± 11.3 yr). Body structure measurements were performed using a standardized method of multichannel bioimpedance analysis (BIA), using a body structure analyzer - InBody 720. The total sample was divided into two subsamples according to sex, where every subsample was divided into five different age groups.The mean PBF values of the Male total sample were 18.2 ± 8.0 % and the female total sample was 28.3 ± 9.2 %. Results of Kruskal-Wallis ANOVA with Dwass-Steel-Critchlow-Fligner post-hock showed that there are statistically significant differences (p < 0.001) between all age groups among themselves except groups 50 - 60 and 60 - 65 (p = 0.09). Analysis of obesity prevalence according to the PBF indicator in different age groups revealed the existence of statistically significant (p < 0.001) trends of increasing obesity with age, both in men and women. Based on the result of this study, it can be concluded that most of the Serbian working population are in the range of normal PBF values, excluding the male 30-39.9 yr and female 60-65 yr age categories as groups which are more prone to obesity levels.

RESUMEN: La prevalencia de obesidad y las tendencias de PBF relacionadas con la edad se determinaron en una muestra de 8100 personas, de las cuales 4955 eran hombres (Edad = 31,2 ± 10 años) y 3145 eran mujeres (Edad = 32,1 ± 11,3 años). Las mediciones de la estructura corporal se realizaron utilizando un método estandarizado de análisis de bioimpedancia multicanal (BIA), usando un analizador de estructura corporal - InBody 720. La muestra total se dividió en dos submuestras, según el sexo, donde cada muestra se dividió en cinco grupos de edad diferentes. Los valores de PBF de la muestra total masculina fueron 18,2 ± 8,0% y la muestra total femenina fue 28,3 ± 9,2%. Los resultados del ANOVA de Kruskal-Wallis con Dwass-Steel-Critchlow- Fligner post-corvejón mostraron que existían diferencias estadísticamente significativas (p <,001) entre todos los grupos de edad, excepto los grupos 50 - 60 y 60 - 65 (p = 0.09). El análisis de la prevalencia de obesidad según el indicador PBF en diferentes grupos de edad, reveló la existencia de tendencias estadísticamente significativas (p < 0,001) de un aumento de la obesidad con la edad, tanto en los hombres como en las mujeres. Con base en el resultado de este estudio, se puede concluir que la mayoría de la población activa de Serbia se encuentra en el rango de valores normales de PBF, excluyendo las categorías de edad de hombres de 30 a 39,9 años y de mujeres de 60 a 65 años, como los grupos que son más propensos a los niveles de obesidad.

História da obesidade na classificação internacional de doenças (CID): de 1900 a 2018 / History of obesity in the international classification of diseases (ICD): 1900 to 2018

O presente artigo teve como objetivo descrever o histórico da inserção da condição clínica denominada atualmente de "obesidade" nas onze revisões da Classificação Internacional de Doenças (CID), publicadas pela Organização Mundial da Saúde (OMS), entre os anos 1900 e 2018. Para tanto, buscou-se pela palavra-chave "obesity" nos documentos, realizando, posteriormente, uma descrição e uma análise da presença, modo de inserção e as mudanças ocorridas ao longo do tempo. Os resultados demonstraram que a condição já foi e continua sendo inserida como sintoma, morbidade, coREVSmorbidade, causa de mortalidade e/ou doença. Concluiu-se que há uma grande inconsistência lógica nos princípios que regem a classificação.

This article aimed at describing the history of insertion of the clinical condition currently referred to as "obesity" in the eleven revisions of the International Classification of Diseases (ICD) published by the World Health Organization (WHO) between 1900 and 2018. For this purpose, a search for the keyword obesity was performed in the documents, with subsequent description and analysis of the presence, mode of insertion, and changes occurring over time. The results demonstrated that the condition has been and continues to be inserted as symptom, morbidity, comorbidity, cause of mortality and/or disease. It can be concluded that there is a massive logical inconsistency in the principles that govern the classification.

Associação entre os sintomas depressivos e a gordura corporal em pacientes com doença renal crônica em hemodiálise / Association between depressive symptoms and body fat in chronic kidney patients in hemodialysis

| INTRODUÇÃO: O excesso de gordura corporal causa alterações metabólicas complexas que acentuam na patogênese e progressão da doença renal crônica (DRC). Além disto, os aspectos comportamentais negativos, como sintomas depressivos e o sedentarismo, são comuns e podem estar associados ao acúmulo de gordura corporal em pacientes que realizam tratamento em hemodiálise (HD). OBJETIVO: Verificar a associação entre os sintomas depressivos e a gordura corporal em pacientes com DRC em HD. MÉTODO: Trata-se de um estudo transversal de um centro clínico de HD em Brasília−DF. Trinta e nove pacientes foram incluídos (59,3±16,7; idade). A composição corporal foi avaliada por meio de bioimpedância tetrapolar. O inventário de depressão de Beck foi empregado para mensurar os sintomas depressivos. Para analisar a associação entre os sintomas depressivos e a gordura corporal foi adotado o teste de correlação de Spearman. RESULTADOS: Foi observado uma prevalência de depressão de 17,9%. Os sintomas depressivos foram positivamente correlacionados com a gordura corporal (r = 0,42; p = 0,008). CONCLUSÃO: Em nossos resultados, confirmamos que os sintomas depressivos estão associados à gordura corporal em pacientes com DRC em HD. Estes achados demonstram-se importantes para a prática clínica dos profissionais de saúde, sobretudo, nos aspectos dietéticos e psicológicos em pacientes com DRC, de forma que iniciativas de diagnóstico, prevenção e tratamentos sejam priorizadas com o objetivo de reduzir tais condições.

INTRODUCTION: Excess body fat causes complex metabolic changes that enhance the pathogenesis and progression of chronic kidney disease (CKD). Furthermore, negative behavioral aspects such as depressive symptoms and a sedentary lifestyle are common and may be associated with the accumulation of body fat in patients undergoing hemodialysis (HD) treatment. OBJECTIVE: To verify the association between depressive symptoms and body fat in HD patients. METHODS: This is a cross-sectional study that enrolled thirty-nine patients (59,3 ± 16,7; age). The body composition was evaluated by bioimpedance tetrapolar. Beck's depression inventory was used to measure depressive symptoms. Anda, to analyze possible association between depressive symptoms and body fat, Spearman's correlation test was applied. RESULTS: A depression prevalence of 17.9% was observed. Depressive symptoms were positively correlated with body fat (r = 0.42; p = 0.008). CONCLUSION: Our results confirmed that depressive symptoms were associated with body fat in HD patients. These findings are important for the clinical practice of health professionals, especially in the dietary and psychological aspects; therefore, treatment initiatives for diagnosis, prevention are important to reduce these conditions.

Fatores associados ao elevado percentual de gordura corporal em indivíduos fisicamente ativos / Factors associated with the high body fat percentage in physically active individuals

Introdução: O exercício físico é praticado com diversos objetivos, destacando-se a promoção na mudança da composição corporal, com a redução de gordura e aumento de massa magra. Assim, compreender os fatores que podem estar associados nesta modificação se torna relevante. Objetivo: Analisar os fatores demográficos, estilo de vida, bioquímico, alimentares e de treinamento associados ao percentual de gordura corporal em praticantes de exercício físico em academias. Materiais e Métodos: Estudo transversal com 143 praticantes de exercícios físicos saudáveis, de ambos os sexos. Características sociodemográficas e estilo de vida foram obtidas através da aplicação de questionário. O consumo alimentar foi obtido através de registros alimentares de 24h, considerando as médias de três dias. A composição corporal foi avaliada por meio de avaliação antropométrica e pelo teste de bioimpedância elétrica. A análise estatística contemplou o teste de Shapiro Wilk para verificação da normalidade; o qui-quadrado e exato de Fisher foram usados para avaliar a associação entre as variáveis categóricas e a variável resposta e os testes de Mann-Whitney e t de Student para as contínuas. A regressão de Poisson com variância robusta foi usada para determinar as associações entre variáveis estudadas. O software Stata versão 14.0 foi usado para análise estatística, tendo sido adotado o valor de p <0,05. Resultados: A prevalência de gordura corporal elevada foi de 49,3% nos homens e 79,2% nas mulheres. Os fatores associados foram o maior consumo de proteína e fibras nas mulheres e a concentração de monócitos nos homens. Conclusão: Apesar de se tratar de público fisicamente ativo, observou-se elevado percentual de gordura entre os participantes do estudo e os fatores associados reforçam o caráter multietiológico deste indicador. (AU)

Introduction: Physical exercise is practiced with several objectives, especially the promotion of changes in body composition, with fat reduction and increase in lean mass. Thus, understanding the factors that may be associated with this modification becomes relevant. Objective: To analyze demographic, lifestyle, biochemical, dietary, and training factors associated with the percentage of body fat in practitioners of physical exercise in gyms. Materials and Methods: Cross-sectional study with 143 healthy physical exercise practitioners, of both sexes. Sociodemographic characteristics and lifestyle were obtained through the application of a questionnaire. Food consumption was obtained through 24-hour food records, considering the averages of three days. Body composition was assessed using anthropometric assessment and the electrical bioimpedance test. The statistical analysis included the Shapiro Wilk test to verify normality, the chi-square and Fisher's exact test were used to assess the association between categorical variables and the response variable and the Mann-Whitney and Student t tests for the continuous variables. Poisson regression with robust variance was used to determine the associations between studied variables. Stata software version 14.0 was used for statistical analysis and a value of p <0.05 was adopted. Results: The prevalence of high body fat was 49.3% in men and 79.2% in women. The associated factors were the higher consumption of protein and fibers in women and the concentration of monocytes in men. Conclusion: Despite being a physically active public, a high percentage of fat was observed among the study participants and the associated factors reinforce the multi-etiological character of this indicator. (AU)

Comparação entre autoimagem e índice de massa corporal entre crianças residentes em favela do Rio de Janeiro, 2012 / Comparación entre la autoimagen y el índice de masa corporal entre los niños que viven en una favela en Rio de Janeiro, Brasil, 2012 / Comparison between self-image and body mass index among children living in a slum in Rio de Janeiro, Brazil, 2012

Objetivo: Analisar a concordância/discrepância entre autoimagem corporal e classificação do índice de massa corporal (IMC), segundo tipo de alimentação e influências do ambiente. Métodos: Análise transversal de 195 crianças pré-púberes (≥5 anos), atendidas na Atenção Primária à Saúde (APS), Manguinhos, Rio de Janeiro, Brasil. O IMC foi classificado conforme escore-z. Avaliou-se a autoimagem pela escala de silhuetas para crianças. Estimou-se a associação entre as covariáveis e subestimação/superestimação do IMC em relação à autoimagem, em modelo multinomial. Resultados: Crianças com sobrepeso subestimaram seu IMC, em comparação com a autoimagem, em maior proporção (58,6%) que aquelas com obesidade (22,0%) ou com eutrofia (49,0%). Essa dissociação correlacionou-se com a participação no programa de transferência de renda (RC=2,01 - IC95% 1,04;3,90) e com o consumo diário de alimentos açucarados (RC=3,88 - IC95% 1,05;14,39). Conclusão: A subestimação do IMC entre as crianças com excesso de peso deve ser considerada pela APS, visando aperfeiçoar as práticas de intervenção.

Objetivo: Verificar la correspondencia/divergencia entre autoimagen e índice de masa corporal (IMC), según variables relacionadas al tipo de alimentación e influencia del ambiente. Métodos: Análisis transversal de 195 niños prepúberes (≥5 anos), atendidos en la Atención Primaria de Salud (APS). Se utilizó la clasificación del IMC basada em la puntuación z de la Organización Mundial de la Salud. La autoimagen se evaluó según la escala de silueta validada para niños. Se estimó la asociación de covariables con el resultado de la subestimación/sobreestimación del estado nutricional en modelo multinomial. Resultados: Los niños con sobrepeso subestimaron su IMC, en comparación con la autoimagen, en una mayor proporción (58.6%) que los obesos (22.0%) y eutróficos (49.0%). Esta disociación de la representación se asoció con la participación en el programa de transferencia de renta (odds ratio [OR] = 2,01 - IC95% 1,04;3,90) y con el consumo diario de dulces (OR=3,88 - IC95% 1,05;14,39). Conclusión: La subestimación del IMC de los niños con sobrepeso debe tenerse en cuenta para la mejor intervención en las prácticas de atención primaria de salud.

Objective: To analyze agreement/discrepancy between body self-image and Body Mass Index (BMI), according to variables related to type of food and environment influence. Methods: This was a cross-sectional analysis of 195 prepubescent children (≥5 anos), attending a Primary Health Care service in Manguinhos, Rio de Janeiro. Z-scores were applied to classify BMI. Self-image was collected using the figure rating scale (silhouettes) validated for children. A multinomial model was used to estimate covariate association with the underestimated/overestimated BMI outcome in relation to self-image. Results: Overweight children underestimated their BMI, as compared with self-image, more often (58.6%) than obese children (22.0%) and children with adequate BMI (49.0%). This dissociation was correlated to participation in a cash transfer program (OR=2.01 - 95%CI 1.04;3.90) and daily consumption of sugar-sweetened foodstuffs (OR=3.88 - 95%CI 1.05;14.39). Conclusion Underestimation of BMI among overweight children should be taken into account by Primary Health Care services, in order to enhance intervention practices.

Quality of life and its relationship with different anthropometric indicators in adults with obesity / Qualidade de vida e sua relação com diferentes indicadores antropométricos em adultos com obesidade

Abtract Introduction: Obesity compromises the quality of life. However, few studies have investigated the influence of different anthropometric indicators on the quality of life of this population. Objective: We aimed to correlate the physical and mental components of quality of life and verify its association with different anthropometric indicators in adults with obesity. Methods: A cross-sectional study was conducted in adults with obesity [body mass index (BMI) ≥ 30 kg/m²]. The quality of life was investigated using the SF-36 questionnaire, with scores ranging from 0 (worst-case scenario) to 100 (best scenario for the outcome). The anthropometric indicators used were BMI, waist circumference, waist/height ratio (WHR), and lean and fat body mass. For analysis, Spearman's correlation and crude and adjusted linear regression for sociodemographic variables were used. Results: A total of 75 subjects (nfemales = 47; µage= 34.8 ± 7.1 years) were included, and their means of the physical and mental components were 64.5 ± 15.9 and 50.8 ± 21.3 points, respectively. The social functioning domain presented a strong positive correlation (r = 0.760) with the mental health domain, and eight moderate correlations (0.400 ≤ r ≥ 0.699) were found between the different domains of the questionnaire. The functional capacity domain and the physical component presented a moderate negative correlation with the WHR (r = -0.402 and r = -0.407, respectively). After adjustment, the WHR was inversely associated with the physical component (β = -1.197; p = 0.002). Conclusion: In adults with obesity, important correlations were observed between the physical and mental components of quality of life, and the waist/height ratio was the only anthropometric indicator correlated and associated with the physical component of the outcome.

Resumo Introdução: A obesidade compromete a qualidade de vida física e mental em função do excesso de peso corporal. Entretanto poucos estudos se propuseram a compreender a influência dos diferentes indicadores antropométricos na qualidade de vida dessa população. Objetivo: Correlacionar os componentes físico e mental da qualidade de vida e verificar a sua associação com diferentes indicadores antropométricos em adultos com obesidade. Métodos: Realizou-se um estudo transversal com adultos com obesidade (índice de massa corporal [IMC] ≥ 30kg/m²). A qualidade de vida foi investigada pelo questionário SF-36, com amplitude de escores de zero (pior cenário) a 100 (melhor cenário para o desfecho). Os indicadores antropométricos foram: IMC, perímetro de cintura, razão cintura/estatura (RCE), massa corporal magra e gorda. Na estatística, empregou-se correlação de Spearman e regressão linear bruta e ajustada para variáveis sociodemográficas. Resultados: Nos 75 sujeitos (nmulheres = 47; µidade = 34,8 ± 7,1 anos), o componente físico apresentou média de 64,5 ± 15,9 pontos e mental de 50,8 ± 21,3 pontos. O domínio de aspecto social apresentou forte correlação positiva (r = 0,760) com o domínio da saúde mental e foram encontradas oito correlações moderadas (0,400 ≤ r ≥ 0,699) entre os distintos domínios do questionário. O domínio capacidade funcional e o componente físico apresentaram moderada correlação negativa com a RCE (r = -0,402 e r = -0,407, respectivamente). Na análise ajustada, a RCE apresentou uma associação inversa com o componente físico (β = -1,197; p = 0,002). Conclusão: Em adultos com obesidade, observou-se importantes correlações entre os componentes físico e mental da qualidade de vida e a razão cintura/estatura foi o único indicador antropométrico correlacionado e associado ao componente físico do desfecho.

Serum ferritin levels among schoolchildren and its correlation with lipid profile and adiposity

To determine the association between serum ferritin levels, lipid profile and adiposity in school-age children. Methods: A cross-sectional study was conducted on obese and non-obese children. Weight, height, waist circumference and blood pressure were measured for all participants. Lipid profile, serum ferritin and glucose were determined and analysed through absorbance. The Spearman correlation was performed for the quantitative variables and a regression analysis was used to determine the interaction between variables. Eighty-nine children were included, with a median age of 9.0 years. Results: When comparing serum ferritin levels in normal weight group, vs. the overweight and obesity group, values were significantly higher in the latter. Serum ferritin correlated positively with BMI (Rho .282, p <0.01), waist circumference (Rho .372, p < 0.01), diastolic blood pressure (Rho .244, p < 0.05), body fat percentage (Rho .375, p < 0.001), insulin (Rho .254, p <.05) and sex (Rho .224, p <.05); and negatively with high-density lipoprotein cholesterol (Rho. -221, p< 0.05). When analysing the significant variables in a multivariate regression model, sex, body mass index, waist circumference, and body fat percentage remained statistically significant (p <0.01). Conclusion: We observed associations between serum ferritin and obesity in Mexican school aged children(AU)

Determinar la asociación entre los niveles de ferritina sérica, el perfil de lípidos y la adiposidad en niños en edad escolar. Metodología: Se realizó un estudio transversal en niños obesos y no obesos. Se midieron el peso, la altura, la circunferencia de cintura y la presión arterial en todos los participantes. El perfil lipídico, la ferritina sérica y la glucosa se determinaron y analizaron mediante absorbancia. Se realizó correlación de Spearman para las variables cuantitativas y se utilizó un análisis de regresión para determinar la interacción entre las variables. Se incluyeron ochenta y nueve niños, con una edad media de 9,0 años. Resultados: Al comparar los niveles de ferritina sérica en el grupo de peso normal, frente al grupo de sobrepeso y obesidad, los valores fueron significativamente más altos en este último. La ferritina sérica se correlacionó positivamente con el IMC (Rho 0,282, p <0,01), la circunferencia de cintura (Rho 0,372, p <0,01), la presión arterial diastólica (Rho 0,244, p <0,05), el porcentaje de grasa corporal (Rho 0,375, p < 0,001), insulina (Rho 0,254, p <0,05) y sexo (Rho 0,224, p < 0,05); y negativamente con colesterol de lipoproteínas de alta densidad (Rho -0,221, p <0,05). Al analizar las variables significativas en un modelo de regresión multivariante, el sexo, el índice de masa corporal, la circunferencia de cintura y el porcentaje de grasa corporal se mantuvieron estadísticamente significativos (p <0,01). Conclusión: Observamos asociaciones entre la ferritina sérica y la obesidad en niños mexicanos en edad escolar(AU)

Relación de la grasa corporal con la alimentación emocional y calidad de la dieta en universitarios de México / Relationship of body fat with emotional eating and quality of diet in university students from Mexico

La obesidad es un problema de salud pública. La comprensión de factores tanto emocionales como dietéticos relacionados a su desarrollo es fundamentales para abordar este problema. El objetivo del presente estudio fue analizar por sexo y edad la relación de la grasa corporal con la alimentación emocional (AE) y la calidad de la dieta (CD) en población universitaria. Se realizó un estudio transversal en el que participaron 367 estudiantes universitarios de medicina (65 % mujeres). El porcentaje de grasa se midió a través de bioimpedancia eléctrica. La alimentación emocional (AE) (emoción, familia, indiferencia, cultura y efecto del alimento) se obtuvo de la escala de AE y la calidad de la dieta (CD)a partir de índice de calidad de la dieta mexicana (ICMX) (suficiente, balanceada, completa, variada e inocua), mediante un cuestionario semicuantitativo de frecuencia de consumo de alimentos. Para identificar qué variables independientes explican el porcentaje de grasa corporal se utilizó la regresión lineal múltiple. Se encontraron diferencias estadísticamente significativas entre sexos, los hombres presentaron valores superiores a las mujeres en edad, peso, altura e IMC (kg/m2), mientras que las mujeres presentaron un mayor porcentaje de grasa corporal respecto a los hombres. La cultura (p=,001) y efecto del alimento (p=,006), factores de la AE, predijeron menor porcentaje de grasa corporal en hombres mayores de 20 años. Resulta necesario implementar programas de salud, que vayan encaminados a un consumo saludable de alimentos mediante actividades recreativas y con el acompañamiento de profesionales de la salud durante la universidad(AU)

Obesity is a public health problem. Understanding both emotional and dietary factors related to its development are essential to address this problem. The objective of this study was to analyze by sex and age the relationship of body fat with emotional eating (EE) and diet quality (DQ) in university population. A cross-sectional study was carried out in which 367 university medical students participated (65% women). Body fat percentage was measured through electrical bioimpedance. Emotional eating (EE) (emotion, family, indifference, culture and effect of food) was obtained from the EE scale and diet quality (DQ) from the Mexican Diet Quality Index (MDQI) (sufficient, balanced, complete, varied and innocuous), using a semi-quantitative food consumption frequency questionnaire. Multiple linear regression was used to identify which independent variables explain body fat percentage. Statistically significant differences were found between sexes, men had higher values than women in age, weight, height, and BMI (kg/m2), while women had a higher body fat percentage compared to men. Culture (p = .001) and effect of food (p = .006), factors of EE, predicted lower body fat percentage in men older than 20 years. It is necessary to implement health programs that are aimed at a healthy consumption of food through recreational activities and with the accompaniment of health professionals during university(AU)

Effect of dietary nutrition on tail fat deposition and evaluation of tail-related genes in fat-tailed sheep

BACKGROUND: The effects of dietary nutrition on tail fat deposition and the correlation between production performance and the Hh signaling pathway and OXCT1 were investigated in fat-tailed sheep. Tan sheep were fed different nutritional diets and the variances in tail length, width, thickness and tail weight as well as the mRNA expression of fat-related genes (C/EBPα, FAS, LPL, and HSL) were determined in the tail fat of sheep at three different growth stages based on their body weight. Furthermore, the correlations between tail phenotypes and the Hedgehog (Hh) signaling pathway components (IHH, PTCH1, SMO, and GLI1) and OXCT1 were investigated. RESULTS: C/EBPα, FAS, LPL, and HSL were expressed with differences in tail fat of sheep fed different nutritional diets at three different growth stages. The results of the two-way ANOVA showed the significant effect of nutrition, stage, and interaction on gene expression, except the between C/EBPα and growth stage. C/EBPα, FAS, and LPL were considerably correlated with the tail phenotypes. Furthermore, the results of the correlation analysis demonstrated a close relationship between the tail phenotypes and Hh signaling pathway and OXCT1. CONCLUSIONS: The present study demonstrated the gene-level role of dietary nutrition in promoting tail fat deposition and related tail fat-related genes. It provides a molecular basis by which nutritional balance and tail fat formation can be investigated and additional genes can be identified. The findings of the present study may help improve the production efficiency of fat-tailed sheep and identify crucial genes associated with tail fat deposition.